PhD Researcher Peptide Immunomodulators

Posted: March 13, 2017 in Europe, Jan-Mar Deadline, Netherlands, Other/Jobs, PhD

The Division Molecular Host Defence of the Department of Infectious Diseases and Immunology has two positions available for PhD students.

An innovative way to help preventing bacterial infections is the modulation of the immune system by molecules that are derived from components of the host’s own innate immune system, such as Host Defence Peptides (HDPs). HDPs are antimicrobial peptides that directly kill bacteria but are currently also acknowledged as an essential part of the regulatory machinery of the immune system. HDPs are among the most active immune-modulating molecules and have the ability of both stimulating immunity as well as dampening the immune response if there is a threat of overstimulation. This combination of activities ensures protection but also reduces the risk for excessive inflammation.

Recent work in our group indicated that HDPs modulate signalling in macrophages by bacterial products. These peptides were shown to enhance sensing of bacterial DNA (via TLR9) and to dampen the LPS-induced inflammation via TLR4. Moreover, a very different response of macrophages was observed if live or dead bacteria were treated with HDPs. This suggests that the efficacy of vaccines may be improved by the addition of these peptides (patent and patents pending).

Considering the properties of peptides that have been developed thus far, we propose that peptides can be produced that improve the efficacy of vaccination. This hypothesis is explored within this project. The aim of this project is to develop technologies that direct the immune response by peptides with tailor-made immunomodulatory properties. The tasks of the candidates are to delineate the mechanisms of immunomodulation by the peptides to improve bacterial vaccines.
Candidate 1 will focus on Gram-positive bacteria and candidate 2 on Gram-negative bacteria. You will be a member of a (virtual) technology center for Bacterial Vaccines (Bac-Vactory) that includes investigators from Utrecht University, VU University Amsterdam, Radboud University Nijmegen, University of Technology Eindhoven, Wageningen Bioveterinary Research and several companies. The project is funded by TTW (STW Perspectief Program).
The Division Molecular Host Defence of the Department of Infectious Diseases and Immunology focuses on host defence peptides and proteins of the innate immune system. The aims of the group are: (1) to understand the mechanisms of action of these molecules and (2) to apply the acquired knowledge to develop new strategies to prevent and treat infections in humans and animals.

Requirements

You should have:

  • a Master’s degree in Life Sciences or equivalent;
  • affinity with immunology and peptide chemistry;
  • interest to collaborate with scientists in academia, research institutes and industry.

Conditions of employment

We offer a full-time temporary appointment for 1 year, with the perspective of prolongation with another 3 years. The gross salary – depending on previous qualifications and experience – starts with €2,191 in the first year and increases to €2,801 per month in the fourth year for a full-time employment (scale P of the Collective Labour Agreement of the Dutch Universities). Salaries are supplemented with a holiday bonus of 8% and a year-end bonus of 8.3% per year. Utrecht University offers excellent secondary benefits including a minimum of 29 leave days, pension plan and flexible employment conditions (multiple choice model). For further information: working at Utrecht University.

Employer

A better future for everyone. This ambition motivates our scientists in executing their leading research and inspiring teaching. At Utrecht University the various disciplines collaborate intensively towards major societal themes. Our focus is on Dynamics of Youth, Institutions, Life Sciences and Sustainability.

The Faculty of Veterinary Medicine is the only academic institution in the Netherlands that trains students to become veterinarians. The Faculty is one of the European leaders in the fields of education, research and patient care. It is accredited by the American Veterinary Medical Association and the Canadian Veterinary Medical Association. The Faculty employs approximately 900 people.

The Department of Infectious Diseases and Immunology is renowned for its expertise in the field of clinical veterinary infectiology, immunology, infection biology, virology, molecular resistance and tick diseases.

Additional information

For more information, please contact Prof Dr Henk P. Haagsman (h.p.haagsman@uu.nl) on (31)-30-253 53 54 or Dr Edwin Veldhuizen (e.j.a.veldhuizen@uu.nl) on (31)-30-253 53 61.

Please do not send your application to these addresses.

Advertisements

Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.